This page presents international journal articles co-authored by Prof. Dr. Selim İsbir, organised by publication year. Each record provides bibliographic information, a short research summary and an original publication link where available.
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1) Demircin M, Arsan S, Paşaoğlu İ, Atasoy S, Sarıgül A, Doğan R, Isbir CS, Yurdakul Y, Bozer AY. Coarctation of the aorta in infants and neonates: Results and assessment of prognostic variables. J Cardiovasc Surg. 1995;36(5):459–464. Link: https://pubmed.ncbi.nlm.nih.gov/8522563/
- Abstract: The study evaluated early surgical outcomes of aortic coarctation repair in neonates and infants and the factors affecting prognosis. The findings showed that the surgical technique and associated anomalies significantly influenced mortality and morbidity.
2) Günal N, Bilgiç A, Lenk MK, Yurdakul Y, Sarıgül A, Isbir CS. Abnormal connection of the inferior vena cava to the left atrium with double outlet right ventricle and heterotaxia: A case report. Cathet Cardiovasc Diagn. 1996;37(3):287–289. Link: https://pubmed.ncbi.nlm.nih.gov/8974808/
- Abstract: A rare case of the inferior vena cava draining into the left atrium in association with double-outlet right ventricle (DORV) and heterotaxy was presented. Imaging and catheterization findings highlighted anatomical details critical to surgical planning.
3) Sarıgül A, Yurdakul Y, Isbir CS, Mercan Ş, Çeliker A. Bicuspid aortic valve and coarctation of aorta. Turk J Pediatr. 1997;39(3):429–432. Link: https://www.turkishjournalpediatrics.org/uploads/pdf_TJP_1341.pdf
- Abstract: Early diagnosis and surgery were associated with better outcomes in patients with a bicuspid aortic valve, which has two leaflets, and coexisting aortic coarctation.
4) Doğan R, Sarıgül A, Isbir CS, Farsak B, Tuncer M, Kılınç K, Demircin M. Beneficial effect of captopril against ischemia-reperfusion injury in the isolated guinea pig hearts. Scand J Clin Lab Invest. 1998;58:119–126. Link: https://pubmed.ncbi.nlm.nih.gov/9587163/
- Abstract: Captopril reduced ischemia–reperfusion injury in isolated guinea pig hearts. Adding the drug to the reperfusion solution and oral preconditioning improved functional recovery.
5) Isbir T, Yılmaz H, Ağachan B, Aydın M, Isbir CS. Association between angiotensin converting enzyme gene polymorphism and coronary artery disease. IUBMB Life. 1999;48:205–207. Link: https://pubmed.ncbi.nlm.nih.gov/10794598/
- Abstract: The association between the ACE gene insertion/deletion polymorphism and coronary artery disease was investigated. The findings suggested that this genetic variant may be associated with susceptibility to coronary artery disease.
6) Akgün S, Civelek A, Isbir CS. Current management of acute leg ischaemia: results of an audit by the Vascular Surgical Society of Great Britain and Ireland. (Letter) Br J Surg. 1999;86:1222–1223. Link: https://pubmed.ncbi.nlm.nih.gov/10576898/
- Abstract: The authors commented on a comprehensive audit of acute leg ischemia management in the United Kingdom and Ireland. The letter highlighted the need to standardize treatment approaches in clinical practice.
7) Isbir CS, Doğan R, Farsak B, Aydın M, Kılınç K. The protective effect of lisinopril on membrane-bound enzymes in myocardial preservation. Cell Biochem Funct. 2000;18:85–91. Link: https://pubmed.ncbi.nlm.nih.gov/10814965/
- Abstract: Lisinopril contributed to myocardial protection by preserving membrane-bound enzyme activities, including Na⁺/K⁺-ATPase and Ca²⁺-ATPase. The results supported a reduction in the adverse effects of oxidative stress on enzyme activity.
8) Isbir CS, Doğan R, Farsak B, Aydın M. The effect of captopril on membrane-bound enzymes in ischemia-reperfusion injury. Cardiovasc Surg. 2000;8(3):192–197. Link: https://pubmed.ncbi.nlm.nih.gov/10799827/
- Abstract: Captopril improved ATPase activities by supporting membrane integrity after ischemia–reperfusion. The findings provided biochemical evidence of the contribution of ACE inhibitors to myocardial recovery.
9) Yaylım I, Isbir CS, Taylor A, Mercan S. Trace element alterations before and after cardiopulmonary bypass in patients undergoing coronary artery bypass grafting. Trace Elem Electroly. 2001;18:16–19. Link: —ResearchGate
- Abstract: Changes in trace element levels before and after coronary bypass surgery were monitored. The findings suggested that cardiopulmonary bypass can cause substantial fluctuations in elements such as zinc, copper and selenium.
10) Isbir CS, Doğan R, Demircin M, Yaylım I, Paşaoğlu I. Aprotinin reduces the IL-8 after coronary artery bypass grafting. Cardiovasc Surg. 2001;9(4):403–406. Link: https://pubmed.ncbi.nlm.nih.gov/11420167/
- Abstract: Aprotinin reduced levels of the proinflammatory cytokine IL-8 after coronary bypass surgery. This effect may help modulate the postoperative inflammatory response.
11) Isbir CS, Doğan R, Tuncer M, Aydın M. The effect of Enalapril Maleat in ischemia-reperfusion injury: Possible role of membrane-bound enzymes. Angiology. 2001;52(1):47–49. Link: https://pubmed.ncbi.nlm.nih.gov/11178788/
- Abstract: Enalapril maleate was reported to support cardiac function by preserving membrane-bound enzymes during ischemia–reperfusion injury. Improved ATPase activities were observed in the experimental model.
12) Tekeli A, Akgün S, Isbir CS, Civelek A, Ak K, Demirtaş G, Sirvancı S, Arbak S, Yaylım I, Çobanoğlu A. Prevention of lung injury by FK 506 following hind limb ischemia and reperfusion model in rats. Revista Portuguesa de Cirurgia Cardio-Toracica e Vascular. 2001;8(20):21–25. Link: TURKISH JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
- Abstract: FK506 reduced lung injury in a model of distant organ injury. The effect was associated with suppression of neutrophil infiltration and inflammatory mediators.
13) Isbir CS, Akgün S, Yılmaz H, Civelek A, Ak K, Tekeli A, Ağachan B, Çobanoğlu A. Is there a role of angiotensin-converting enzyme gene polymorphism in the failure of arteriovenous femoral shunts for hemodialysis? Ann Vasc Surg. 2001;15(4):443–446. Link: https://pubmed.ncbi.nlm.nih.gov/11525534/
- Abstract: The relationship between ACE insertion/deletion polymorphism and arteriovenous fistula thrombosis was examined in hemodialysis patients. The results suggested that the D allele may contribute to the risk of shunt failure.
14) Isbir CS, Ak K, Kurtkaya Ö, Zeybek Ü, Akgün S, Scheithauer BW, Sav A, Çobanoğlu A. Ischemic preconditioning and nicotinamide in spinal cord protection in an experimental model of transient aortic occlusion. Eur J Cardiothorac Surg. 2003;23(6):1028–1033. Link: https://pubmed.ncbi.nlm.nih.gov/12829083/
- Abstract: Ischemic preconditioning and nicotinamide showed neuroprotective effects on the spinal cord in a temporary aortic occlusion model. Combined or individual treatment reduced neurological injury.
15) Isbir CS, Yıldırım T, Akgün S, Civelek A, Aksoy N, Öz M, Arsan S. Coronary artery bypass surgery in patients with severe left ventricular dysfunction. Int J Cardiol. 2003;90:309–316. Link: https://pubmed.ncbi.nlm.nih.gov/12957767/
- Abstract: Mortality and mid-term outcomes of coronary bypass surgery were evaluated in patients with severe left ventricular dysfunction. Acceptable mortality and functional improvement were reported in appropriately selected patients.
16) Baltacıoğlu F, Cimsit NC, Cil B, Cekirge S, Isbir CS. Endovascular stent-graft applications in iatrogenic vascular injuries. Cardiovasc Intervent Radiol. 2003;26(5):434–439. Link: https://pubmed.ncbi.nlm.nih.gov/14753300/
- Abstract: The effectiveness and safety of stent grafts for iatrogenic vascular injuries were presented. This minimally invasive approach was shown to be an effective alternative for emergency repair.
17) Akgün S, Tekeli A, Isbir CS, Civelek A, Ak K, Sirvancı S, Arbak S, Yaylım I, Arsan S. FK 506 to prevent lung injury after hindlimb ischemia and reperfusion in a rat model: An electron microscopic study. Surg Today. 2004;34:678–684. Link: https://pubmed.ncbi.nlm.nih.gov/15290398/
- Abstract: Electron microscopy showed that FK506 reduced ultrastructural lung damage after ischemia–reperfusion. The findings supported a protective effect of immunomodulation against distant organ injury.
18) Isbir S, Ak K. Ischemic Preconditioning and Nicotinamide in Spinal Cord Protection in an Experimental Model of Transient Aortic Occlusion. Eur J Cardiothorac Surg. 2004;24:850–853. Link: https://academic.oup.com/ejcts/article/24/5/852/394846
- Abstract: The protective effect of ischemic preconditioning was highlighted alongside previous experimental findings.
19) Akalın F, Ayabakan C, Dinçer I, Isbir CS, Kıyan G, Karakoç F. Rare cause of pericardial effusion in infancy: Intrapericardial diaphragmatic hernia. Pediatrics International. 2004;46:191. Link: https://pubmed.ncbi.nlm.nih.gov/15085562/
- Abstract: Intrapericardial diaphragmatic hernia was presented as a rare cause of pericardial effusion in an infant. The report emphasized that early diagnosis and surgical repair can be lifesaving.
20) Karahan M, Isbir SC, Baltacıoğlu F, Çağlar MM. False aneurysm of the common femoral vein in a footballer. Br J Sports Med. 2005;39(2):e8. Link: https://pubmed.ncbi.nlm.nih.gov/15737934/
- Abstract: A rare femoral vein pseudoaneurysm in a football player was reported. The importance of imaging and surgical management of traumatic venous lesions was emphasized.
21) Akgün S, Tekeli A, Kurtkaya O, Civelek A, Isbir CS, Ak K, Arsan S, Sav A. Neuroprotective effects of FK-506, L-carnitine and azathioprine on spinal cord ischemia-reperfusion injury. Eur J Cardiothorac Surg. 2004;25:105–110. Link: https://pubmed.ncbi.nlm.nih.gov/14690736/
- Abstract: Experimental findings showed that FK506, L-carnitine and azathioprine reduced spinal cord ischemia–reperfusion injury. Different agents may provide neuroprotection through different mechanisms.
22) Arsan S, Ak K, Isbir SC. Clopidogrel in coronary artery surgery. Eur J Cardiothorac Surg. 2004;26(4):869. Link: https://pubmed.ncbi.nlm.nih.gov/15302077/
- Abstract: This letter shared clinical observations on the role of clopidogrel in coronary surgery. It emphasized the timing of antiplatelet management and bleeding risk.
23) Isbir SC, Ak K, Aksoy N. Platelet function tests predict bleeding and thrombotic events after off-pump coronary bypass grafting. Eur J Cardiothorac Surg. 2005;28(3):514 (comment). Link: https://pubmed.ncbi.nlm.nih.gov/15975815/
- Abstract: The implications of platelet function testing for bleeding and thrombosis in off-pump coronary bypass surgery were discussed. The report highlighted dosing and monitoring strategies relevant to clinical practice.
24) Yıldırım T, Isbir SC, Arsan S. Pulmonary valve endocarditis. Anadolu Kardiyoloji Dergisi. 2005;5:83. Link: Anadolu Dergisi
- Abstract: Pulmonary valve endocarditis was discussed in a case report and review format. Given its rarity, the importance of echocardiography and clinical suspicion was emphasized.
25) Ak K, Akgün S, Tecimer T, Isbir CS, Civelek A, Tekeli A, Arsan S, Çobanoğlu A. Determination of histopathologic risk factors for postoperative atrial fibrillation in cardiac surgery. Ann Thorac Surg. 2005;79(6):1970–1975. Link: https://pubmed.ncbi.nlm.nih.gov/15919294/
- Abstract: Postoperative atrial fibrillation was associated with the degree of myolysis and apoptosis in right atrial muscle cells. Histopathological findings may provide useful information for risk assessment.
26) Yılmaz H, Isbir SC, Ağachan B, Ergen A, Farsak B, Isbir T. C677T mutation of methylenetetrahydrofolate reductase gene and serum homocysteine levels in Turkish patients with coronary artery disease. Cell Biochem Funct. 2006;24(1):87–90. Link: https://pubmed.ncbi.nlm.nih.gov/15977293/
- Abstract: The distribution of the MTHFR C677T mutation and homocysteine levels was examined in Turkish patients with coronary artery disease. The genotype–phenotype relationship contributed to assessment of atherothrombotic risk.
27) Koray A(K), Tekeli A, Isbir CS. Apoptosis in ischemic spinal cord injury. J Thorac Cardiovasc Surg. 2006;131(5):1212–1213; author reply 1213. Link: https://pubmed.ncbi.nlm.nih.gov/16631667/
- Abstract: A short article and reply discussed the role of apoptosis in ischemic spinal cord injury associated with aortic surgery. Interpretation of experimental and clinical data highlighted future research directions.
28) Gunaydin S, McCusker K, Vijay V, Isbir CS, Sari T, Onur MA, Gürpınar A, Sezgin A, Sargon MF, Tezcaner T, Zorlutuna Y. Comparison of polymethoxyethylacrylate-coated circuits with leukocyte filtration and reduced heparinization protocol on heparin-bonded circuits in different risk cohorts. Perfusion. 2006;21(6):329–342. Link: https://pubmed.ncbi.nlm.nih.gov/17312857/
- Abstract: A PMEA-coated circuit combined with leukocyte filtration and reduced heparinization decreased inflammatory responses and platelet interactions compared with heparin-coated circuits. Its potential to reduce blood product use and atrial fibrillation in high-risk patients was highlighted.
29) Civelek A, Ak K, Kurtkaya O, Tekeli A, Isbir CS, Nargileci E, Arsan S, Sav A. Effect of a low molecular weight heparin molecule, dalteparin, on cellular apoptosis and inflammatory process in an incisional wound-healing model. Surg Today. 2007;37(5):406–411. Link: https://pubmed.ncbi.nlm.nih.gov/17468823/
- Abstract: The effects of dalteparin on inflammation and apoptosis were studied in an incisional wound-healing model. Low-molecular-weight heparin could alter healing dynamics by suppressing the early inflammatory response.
30) Isbir SC, Ak K, Tekeli A, Civelek A, Atalan N, Arsan S. Coronary artery bypass grafting in idiopathic myelofibrosis: a case report. Heart Surg Forum. 2007;10(1):E55–E56. Link: https://pubmed.ncbi.nlm.nih.gov/17258029/
- Abstract: Perioperative management and hemostatic challenges during coronary bypass surgery in a patient with idiopathic myelofibrosis were described. The case offered practical approaches to surgical planning in patients with hematological comorbidities.
31) Ak K, Isbir SC, Tekeli A, Ergen A, Atalan N, Dogan S, Civelek A, Arsan S. Presence of lipoprotein lipase S447X stop codon affects the magnitude of interleukin 8 release after cardiac surgery with cardiopulmonary bypass. J Thorac Cardiovasc Surg. 2007;134(2):477–483. Link: https://pubmed.ncbi.nlm.nih.gov/17662793/
- • Patients carrying the LPL S447X variant had lower IL-8 release after cardiopulmonary bypass. The findings suggest that genetic markers may help predict bypass-related inflammation. (PubMed)
32) Isbir SC, Tekeli A, Ergen A, Yilmaz H, Ak K, Civelek A, Zeybek U, Arsan S. Genetic polymorphisms contribute to acute kidney injury after coronary artery bypass grafting. Heart Surg Forum. 2007;10(6):E439–E444. Link: https://pubmed.ncbi.nlm.nih.gov/17921131/
- An association was found between certain gene polymorphisms and acute kidney injury after coronary bypass surgery. The results suggest that genetic profiling may help predict the risk of renal complications. (PubMed)
33) Isbir SC, Ergen A, Tekeli A, Zeybek U, Gormus U, Arsan S. The effect of NQO1 polymorphism on the inflammatory response in cardiopulmonary bypass. Cell Biochem Funct. 2008;26(4):534–538. Link: https://pubmed.ncbi.nlm.nih.gov/18098117/
- NQO1 variants were shown to influence cytokine responses, particularly IL-6, during cardiopulmonary bypass. The study highlights the value of genotyping for individualized anti-inflammatory strategies. (PubMed)
34) Isbir SC, Ergen A, Yılmaz H, Tekeli A, Arsan S. Effect of Ala16Val genetic polymorphism of MnSOD on antioxidant defence capacity and inflammatory response in open heart surgery. In Vivo. 2008;22(1):147–151. Link: https://pubmed.ncbi.nlm.nih.gov/18396798/
- MnSOD Ala16Val polymorphism was associated with the severity of oxidative stress and inflammation in open-heart surgery. This finding supports a role for genetic differences in postoperative recovery. (PubMed)
35) Akgun S, Isbir CS, Yildirim T, Civelek A, Arsan S. Results of adjunctive coronary endarterectomy in 548 patients. Heart Surg Forum. 2008;11(2):E66–E70. Link: https://pubmed.ncbi.nlm.nih.gov/18430657/
- Outcomes were reported for 548 patients who underwent coronary endarterectomy during bypass surgery for extensive coronary disease. Mortality was higher than with standard bypass surgery but remained acceptable. The procedure was presented as a possible last resort for diffuse vascular lesions. (PubMed)
36) Ergen A, Isbir CS, Tekeli A, Isbir T. Investigation of ABCA1 C69T and G-191C polymorphisms in coronary artery disease. In Vivo. 2008;22(2):187–190. Link: https://pubmed.ncbi.nlm.nih.gov/18468402/
- The association of ABCA1 C69T and G-191C polymorphisms with coronary artery disease was examined; C69T was notably related to some lipid measures. The results point to a genetic component of atherosclerosis risk through HDL metabolism. (PubMed)
37) Ak K, Atalan N, Tekeli A, Isbir CS, Civelek A, Emekli N, Arsan S. Thromboelastography and its use in cardiac surgery. Anadolu Kardiyol Derg. 2008;8(2):154–162. Link: https://pubmed.ncbi.nlm.nih.gov/18400638/
- Thromboelastography (TEG) provides a dynamic assessment of hemostasis and can help reduce microvascular bleeding and unnecessary transfusions. This article summarizes its indications and clinical use in cardiac surgery. (PubMed)
38) Tekeli A, Isbir CS, Ergen A, Görmüş U, Bozkurt N, Timirci O, Arsan S, Isbir T. APE1 and XRCC3 polymorphisms and myocardial infarction. In Vivo. 2008;22(4):477–480. Link: https://pubmed.ncbi.nlm.nih.gov/18712175/
- The article examined associations between myocardial infarction and variants in the DNA repair genes APE1 and XRCC3. The findings support a role for genomic stability and repair pathways in atherosclerosis. (PubMed)
39) Civelek A, Ak K, Akgün S, Isbir SC, Arsan S. Tricuspid valve replacement: an analysis of risk factors and outcomes. Thorac Cardiovasc Surg. 2008;56(8):456–460. Link: https://pubmed.ncbi.nlm.nih.gov/19012209/
- Risk factors affecting mortality and complications after tricuspid valve replacement were analyzed. Previous mitral valve surgery and more advanced symptoms were associated with adverse outcomes. (PubMed)
40) Akgün S, Ak K, Tuğlular S, Isbir CS, Arsan S. Median sternotomy for an unexpected complication of permanent hemodialysis catheters: “Stuck catheter”. VASA. 2008;37:293–296. Link: https://pubmed.ncbi.nlm.nih.gov/18690600/
- Adherence of tunneled central venous hemodialysis catheters to the vessel wall required median sternotomy in two rare cases. The report emphasizes awareness of the stuck-catheter complication and the need for surgical preparedness with long-term catheter use. (PubMed)
41) Aydoğan HY, Isbir CS, Kurnaz Ö, Görmüş U, Isbir T. Association of Lipoprotein Lipase S477X and Apolipoprotein E Genotypes with Low Density Lipoprotein Subfractions in Turkish Patients with Coronary Artery Disease. In Vivo. 2009;23(1):155–162. 🔗 https://pubmed.ncbi.nlm.nih.gov/19368142/
- The relationship of LPL S447X and ApoE genotypes with LDL subfractions was examined in Turkish patients with coronary artery disease. Genetic variants were found to influence lipoprotein profiles and atherosclerotic risk.
42) Ak K, Adademir T, Isbir CS, Arsan S. Right ventricular mural endocarditis presenting as an isolated apical mass in a non-addict patient with congenital deafness and aphasia. Interact Cardiovasc Thorac Surg. 2009;8(4):498–500. 🔗 https://pubmed.ncbi.nlm.nih.gov/19155224/
- A rare case of an endocarditis mass at the right ventricular apex was presented in a patient without a history of intravenous drug use. Congenital deafness and aphasia were also present.
43) Ak K, Isbir CS, Arsan S. A simple maneuver on sternal saw facilitates to perform curved sternal mini-incisions like J- and C-shaped partial sternotomies. J Card Surg. 2009;24(4):454–456. 🔗 https://pubmed.ncbi.nlm.nih.gov/19583619/
- A simple modification of the sternal saw enabled safe partial sternotomy incisions, offering a practical solution for minimally invasive cardiac surgery.
44) Kurnaz O, Aydoğan HY, Isbir CS, Tekeli A, Isbir T. Is LOX-1 K167N polymorphism protective for coronary artery disease? In Vivo. 2009;23(6):969–973. 🔗 https://pubmed.ncbi.nlm.nih.gov/20023241/
- The potential protective role of the LOX-1 K167N polymorphism in coronary artery disease was investigated. The findings suggested that this variant may reduce atherosclerosis risk.
45) Küçükhüseyin O, Aydoğan HY, Isbir CS, Isbir T. Associations of -374T/A polymorphism of receptor for advanced glycation end products (RAGE) gene in Turkish diabetic and non-diabetic patients with coronary artery disease. In Vivo. 2009;23(6):949–954. 🔗 https://pubmed.ncbi.nlm.nih.gov/20023238/
- The RAGE -374T/A polymorphism was investigated in Turkish coronary artery disease patients with and without diabetes. The findings suggested a role for this genetic variant in atherosclerotic processes.
46) Ak K, Isbir CS, Bozkurt S, Civelek A, Arsan S. Eosinophilic periarteritis of the left internal thoracic artery graft. Anadolu Kardiyol Derg. 2009;9(5):423–425. 🔗 https://pubmed.ncbi.nlm.nih.gov/19819798/
- A rare case of eosinophilic periarteritis in a left internal thoracic artery graft during coronary bypass surgery was reported. Histopathology suggested that unexpected immune mechanisms may underlie graft complications.
47) Ak K, Isbir CS, Tetik S, Atalan N, Tekeli A, Aljodi M, Civelek A, Arsan S. Thromboelastography-based transfusion algorithm reduces blood product use after elective CABG: A prospective randomized study. J Card Surg. 2009;24(4):404–410. 🔗 https://pubmed.ncbi.nlm.nih.gov/19583608/
- A prospective randomized study found that a TEG-based transfusion algorithm reduced blood product use after elective coronary bypass surgery, offering advantages for patient safety and resource use.
48) Yıldızeli B, Isbir CS. Pulmonary thromboendarterectomy. Anadolu Kardiyol Derg. 2010;10 Suppl 2:31–38. 🔗 https://pubmed.ncbi.nlm.nih.gov/20819754/
- The article examined pulmonary thromboendarterectomy, the surgical treatment for chronic thromboembolic pulmonary hypertension, in detail. It emphasized low mortality and morbidity with appropriate patient selection in experienced centers.
49) Tetik S, Ak K, Şahin Y, Gülsoy O, Isbir CS, Arsan S, Yardımcı T. Clopidogrel provides significantly greater inhibition of platelet activity than aspirin when combined with atorvastatin after coronary artery bypass grafting: A prospective randomized study. Clin Appl Thromb Hemost. 2010;16(2):189–198. 🔗 https://pubmed.ncbi.nlm.nih.gov/19703819/
- After coronary bypass surgery, clopidogrel plus atorvastatin suppressed platelet activity more than aspirin plus atorvastatin. The combination was suggested to enhance postoperative antithrombotic efficacy.
50) Tetik S, Ak K, Şahin Y, Gülsoy O, Isbir CS, Arsan S, Yardımcı T. Postoperative statin therapy attenuates the intensity of systemic inflammation and increases fibrinolysis after coronary artery bypass grafting. Clin Appl Thromb Hemost. 2011;17(5):526–531. 🔗 https://pubmed.ncbi.nlm.nih.gov/20805103/
- Postoperative statin therapy reduced the systemic inflammatory response and increased fibrinolysis after coronary bypass surgery. The findings highlighted anti-inflammatory benefits beyond lipid lowering.
51) Ergen A, Isbir CS, Timirci O, Tekeli A, Isbir T. Effects of myeloperoxidase -463 G/A gene polymorphism and plasma levels on coronary artery disease. Mol Biol Rep. 2011;38(2):887–891. 🔗 https://pubmed.ncbi.nlm.nih.gov/20440526/
- The effects of the MPO -463 G/A polymorphism and plasma levels on coronary artery disease were examined. The findings indicated that the variant may influence cardiovascular risk through inflammation.
52) Ak K, Arsan S, Akalın F, Gursu O, Isbir S. Autologous right pulmonary artery tissue for repair of left pulmonary artery originating from left patent ductus arteriosus in a patient with tetralogy of Fallot and absent pulmonary valve. Pediatr Cardiol. 2011;32(7):986–989. 🔗 https://pubmed.ncbi.nlm.nih.gov/21424710/
- A case of tetralogy of Fallot with absent pulmonary valve was presented in which autologous tissue was successfully used to reconstruct the left pulmonary artery.
53) Gürsu Ö, Isbir S, Ak K, Özben B, Türköz HK, Dal D, Arsan S. Testicular germ cell tumor metastatic to the right atrium. J Card Surg. 2011;26(3):276–279. 🔗 https://pubmed.ncbi.nlm.nih.gov/21450078/
- A testicular germ cell tumor with metastasis to the right atrium was reported. This rare presentation drew attention to routes of tumor spread.
54) Görmüş U, Kahraman OT, Isbir S, Tekeli A, Isbir T. MMP2 gene polymorphisms and MMP2 mRNA levels in patients with superficial varices of lower extremities. In Vivo. 2011;25(3):387–391. 🔗 https://pubmed.ncbi.nlm.nih.gov/21576419/
- MMP2 gene polymorphisms and mRNA levels were examined in patients with lower-limb varicose veins. The study suggested that MMP2 may play an important role in venous wall remodeling.
55) Küçükhüseyin O, Yılmaz-Aydoğ an H, Isbir CS, Isbir T. Is there any association between Gly82Ser polymorphism of RAGE gene and Turkish diabetic and non-diabetic patients with coronary artery disease? Mol Biol Rep. 2012;39(4):4423–4428. 🔗 https://pubmed.ncbi.nlm.nih.gov/21922169/
- The relationship between the RAGE Gly82Ser polymorphism and diabetes was evaluated in Turkish patients with coronary artery disease. The findings suggested a possible role in atherosclerosis pathogenesis.
56) Adademir T, Ak K, Aljoudi M, Elçi ME, Arsan S, Isbir S. The effects of pulsatile cardiopulmonary bypass on acute kidney injury. Int J Artif Organs. 2012;35(7):511–519. 🔗 https://pubmed.ncbi.nlm.nih.gov/22965192/
- Pulsatile and standard cardiopulmonary bypass were compared; pulsatile flow reduced the development of acute kidney injury. The findings highlight the importance of perfusion patterns in renal protection.
57) Gürsu Ö, Baltacıoğlu F, Ak K, Arsan S, Aljodi M, Elçi E, Kırca G, Isbir S. Endovascular repair of a thoracoabdominal aortic aneurysm using ascending aorta as an access route in Leriche syndrome: a case report. Turk Gogus Kalp Dama. 2013;21(4):1102–1104. 🔗 https://pubmed.ncbi.nlm.nih.gov/24179647/
- A thoracoabdominal aortic aneurysm was successfully repaired endovascularly through the ascending aorta via a small incision in a patient with Leriche syndrome. This approach was presented as an alternative when standard femoral access was unavailable.
58) Isbir CS, Birkan Y. Transcatheter Aortic Valve Implantation and Atrioventricular Valve Regurgitation (Letter). Ann Thorac Surg. 2013;96(5):1531–1532. 🔗 https://pubmed.ncbi.nlm.nih.gov/24112646/
- Clinical observations and comments on atrioventricular valve regurgitation after TAVI were shared. The letter emphasized the need for multidisciplinary follow-up of complications.
59) Gürsu Ö, Isbir S, Ak K, Gerin F, Arsan S. Comparison of new technology integrated and nonintegrated arterial filters used in cardiopulmonary bypass surgery: a randomized, prospective and single blind study. Biomed Res Int. 2013;2013:682597. 🔗 https://pubmed.ncbi.nlm.nih.gov/24383001/
- New-generation integrated arterial filters were compared with standard filters during cardiopulmonary bypass. Integrated filters reduced microemboli and the inflammatory response.
60) Isbir S, Birkan Y, Ak K, Elçi E, Kararmaz A. Direct transaortic transcatheter aortic valve implantation. Turk Gogus Kalp Dama. 2014;22(2):403–406. 🔗 https://pubmed.ncbi.nlm.nih.gov/24835805/
- Transaortic TAVI was successfully performed in a high-risk patient. The study supported the safety of direct aortic access in appropriately selected cases.
61) Görmüş U, Timirci KÖ, Ergen A, Kunt AT, Isbir S, Dalan AT, Isbir T. Expression levels of Elastin and related genes in human varicose veins. Folia Biol (Praha). 2014;60:68-73. 🔗 PubMed
- Expression levels of elastin and related genes were examined in patients with varicose veins. The findings indicated an important role for impaired elastin synthesis in varicose vein formation.
62) Ak K, Isbir S, Çinçin A, Kararmaz A, Arsan S. Direct transapical implantation of an endocardial pacing lead to the left ventricle: an alternate pacing site after tricuspid valve replacement. J Card Surg. 2014;29(2):290-2. 🔗 PubMed
- After tricuspid valve replacement, a pacing lead was implanted directly into the left ventricular endocardium through a transapical approach. The method offered a reliable alternative when the conventional right ventricular route was unavailable.
63) Özturk YN, Ak K, Erkek N, Besci T, Isbir S, Arsan S. Veno-venous extracorporeal membrane oxygenation in a deeply hypoxemic infant with persistent air leakages: the first successful pediatric veno-venous extracorporeal membrane oxygenation case report in Turkey. Turk Pediatri Ars. 2014;49(1):66-9. 🔗 PubMed
- VV-ECMO was successfully used in an infant with severe hypoxemia and persistent air leakage. The report described the first successful pediatric VV-ECMO application in Türkiye.
64) Isbir S, Ak K, Aslantaş M, Kepez A, Cinel İ, Arsan S. Peripartum cardiomyopathy mimicking acute aortic dissection: successful salvage with extracorporeal membrane oxygenation support. Turk Gogus Kalp Dama. 2014;22(4):843-6. 🔗 PubMed
- Peripartum cardiomyopathy mimicking acute aortic dissection was successfully treated with ECMO support. The case highlighted the lifesaving role of early diagnosis and ECMO.
65) Ak K, Isbir S, Kepez A, Turkoz K, Elci E, Arsan S. Large lipomatous hypertrophy of the interventricular septum. Tex Heart Inst J. 2014;41(2):231-3. 🔗 PubMed
- A case of extensive lipomatous hypertrophy of the interventricular septum was presented. Imaging played an important role in diagnosing and managing this rare condition.
66) Akhundova A, Samedov F, Cincin A, Tigen K, Isbir S, Ahiskali AR, Sari İ. Giant left atrial myxoma with dual coronary supply presenting with recurrent stroke. Herz. 2015;40(2):318-20. 🔗 PubMed
- A giant left atrial myxoma supplied by two coronary vessels presented with recurrent stroke. Surgical removal of the tumor illustrated the clinical consequences of rare anatomical variants.
67) Kunt AT, Isbir S, Gormus U, Kahraman OT, Arsan S, Yilmaz SG, Isbir T. Polymorphisms of MMP9 and TIMP2 in patients with varicose veins. In Vivo. 2015;29(4):461-5. 🔗 PubMed
- MMP9 and TIMP2 gene polymorphisms were investigated in patients with varicose veins. The findings suggested that these variants may contribute to disease development.
68) Kucukhuseyin O, Toptas B, Timirci-Kahraman O, Isbir S, Karsidag K, Isbir T. The effect of GHR/exon-3 polymorphism and serum GH, IGF-1 and IGFBP-3 levels in diabetes and coronary heart disease. In Vivo. 2015;29(3):371-8. 🔗 PubMed
- The relationships of GHR exon-3 polymorphism and GH, IGF-1 and IGFBP-3 levels with diabetes and coronary artery disease were examined. Some variants may influence cardiometabolic risk by altering the endocrine profile.
69) Ulger Toprak N, Bozan T, Birkan Y, Isbir S, Soyletir G. Butyricimonas virosa: the first clinical case of bacteraemia. New Microbes New Infect. 2015;4:7-8. 🔗 PubMed
- The first reported case of human bacteremia caused by Butyricimonas virosa was described, highlighting the clinical significance of this newly identified bacterium.
70) Atalan N, Karagedik H, Acar L, Isbir S, Yilmaz SG, Ergen A, Isbir T. Analysis of Toll-like Receptor 9 gene polymorphisms in sepsis. In Vivo. 2016;30(5):639-43. 🔗 PubMed
- TLR9 gene polymorphisms were examined in patients with sepsis. Some variants may influence the development and clinical course of sepsis.
71) Koray A, Akalın F, Şaylan Çevik B, Isbir S, Arsan S. Disseminated Peripheral Mycotic Aneurysms and Septic Embolizations Related to an Infected Stent Deployed for Restenosis of Surgically Repaired Supravalvular Aortic Stenosis. World J Pediatr Congenit Heart Surg. 2016;7(1):104-7. 🔗 PubMed
- A rare case of extensive peripheral mycotic aneurysms and septic emboli following an infected stent was reported. The findings illustrated the serious complications that stent infections can cause.
72) Altinkilic EM, Isbir S, Gormus U, Yilmaz SG, Dalan AB, Duman S, Isbir T. RRM1, RRM2 and ERCC2 gene polymorphisms in coronary artery disease. In Vivo. 2016;30(5):611-5. 🔗 PubMed
- RRM1, RRM2 and ERCC2 gene polymorphisms were examined in patients with coronary artery disease. Genetic differences in DNA repair mechanisms may contribute to atherosclerosis development.
73) Ak K, Demirbaş E, Ataş H, Birkan Y, Akalın F, Cobanoglu A, Arsan S, Isbir S. Results of pericardiectomy for constrictive pericarditis: single-center experience. Herz. 2017;42(1):75-83. 🔗 PubMed
- Outcomes of pericardiectomy for constrictive pericarditis were evaluated. The operation was effective in improving survival and functional status.
74) Isbir S, Hamidov A, Seven İE, Ak K. Massive hemoptysis related to contained rupture of syphilitic aortic aneurysm into the pulmonary parenchyma. J Thorac Cardiovasc Surg. 2017;154(1):23-6. 🔗 PubMed
- A rare case of massive hemoptysis caused by a syphilitic aortic aneurysm with a contained rupture into the lung parenchyma was presented. The case emphasized the severity of late complications of syphilitic aneurysms.
75) Ak K, Ak E, Dericioglu O, Canak T, Akbuga J, Ozkan N, Cetinel S, Isbir S, Arsan S, Cobanoglu A. Tacrolimus-Eluting Suture Inhibits Neointimal Hyperplasia: An Experimental In Vivo Study in Rats. Eur J Vasc Endovasc Surg. 2017;53(3):431-7. 🔗 PubMed
- In an experimental rat study, tacrolimus-coated sutures reduced neointimal hyperplasia. This may represent a new approach to preventing restenosis in vascular surgery.
76) Ayhan H, Görmüş U, Isbir S, Yılmaz GS, Isbir T. SCARB1 gene polymorphisms and HDL subfractions in coronary artery disease. In Vivo. 2017;31(5):873-6. 🔗 PubMed
- The relationship between SCARB1 gene polymorphisms and HDL subfractions was investigated in patients with coronary artery disease. SCARB1 variants may affect lipoprotein metabolism and cardiovascular risk.
77) Ak K, Hamidov A, İleri Ç, Tigen K, Isbir S, Arsan S. Correction of cortriatriatum sinister with classical Raghib’s complex using an extracardiac conduit. J Card Surg. 2017;32(12):729-31. 🔗 PubMed
- Cor triatriatum sinister associated with Raghib complex was corrected using an extracardiac conduit. The method offered an alternative surgical option for rare congenital anomalies.
78) Isbir S, Arsan S, Ak K, Cobanoglu A. The Perceval Sutureless Valve in Aortic Root Reoperation. J Heart Valve Dis. 2017;26(6):741-3. 🔗 PubMed
- A Perceval sutureless bioprosthetic valve was successfully used in a patient undergoing reoperation for aortic regurgitation after valve-sparing aortic aneurysm repair at another center. The case highlighted the advantages of sutureless valves in complex reoperations.
79) Tekin G, Isbir S, Şener G, Çevik Ö, Çetinel Ş, Dericioğlu O, Arsan S, Çobanoğlu A. The preventive and curative effects of melatonin against abdominal aortic aneurysm in rats. J Vasc Surg. 2018;67(5):1546-55. 🔗 PubMed
- A rat study demonstrated both preventive and therapeutic effects of melatonin against abdominal aortic aneurysm. Its anti-inflammatory and antioxidant properties may have potential for vascular protection.
80) Yılmaz SG, Isbir S, Kunt AT, Isbir T. Circulating microRNAs as novel biomarkers for atherosclerosis. In Vivo. 2018;32(3):561-5. 🔗 PubMed
- The potential of circulating microRNAs as biomarkers of atherosclerosis was examined. Certain microRNA profiles may assist early diagnosis and risk stratification.
81) Isbir S. The Future of surgical aortic valve replacement and the role of sutureless technology. Minerva Cardioangiol. 2018;66(2):213-20. 🔗 PubMed
- The future role of sutureless technology in surgical aortic valve replacement was evaluated. Shorter operative times and low complication rates were highlighted as reasons for its growing importance.
82) Solim LA, Gencan İA, Çelik B, Ataacar A, Koç U, Büyükören B, Güngör G, Isbir S. Endothelial Lipase Gene Polymorphism (584C/T) in Coronary Artery Patients Among a Turkish Population. In Vivo. 2018;32(5):1105-9. 🔗 PubMed
- Endothelial lipase gene polymorphism was investigated in Turkish patients with coronary artery disease. The variant may be associated with lipid metabolism and atherosclerosis development.
83) Arıkan DG, Isbir S, Gulec S, Isbir T. Characteristics of coronary artery disease patients who have a polymorphism in cholesterol ester transfer protein (CETP) gene. In Vivo. 2019;33(3):787-92. 🔗 PubMed
- Clinical characteristics of coronary artery disease patients carrying CETP gene polymorphisms were examined. CETP variants were associated with lipid profiles and cardiovascular risk.
84) Elçi ME, Kahraman A, Mutlu E, İspir CS. Effects of minimal extracorporeal circulation on the systemic inflammatory response and the need for transfusion after coronary bypass grafting surgery. Cardiol Res Pract. 2019;2019:1726150. 🔗 PubMed
- The effects of minimal extracorporeal circulation on inflammation and transfusion requirements in coronary bypass surgery were examined. The method reduced systemic inflammation and blood product use.
85) Weitz JI, Haas S, Ageno W, Goldhaber SZ, Turpie AGG, Goto S, Angchaisuksiri P, Nielsen JD, Kayani G, Farjat AE, Schellong S, Bounameaux H, Mantovani LG, Prandoni P, Kakkar AK; GARFIELD-VTE investigators. Cancer associated thrombosis in everyday practice: perspectives from GARFIELD-VTE. J Thromb Thrombolysis. 2020;50(2):267-77. 🔗 PubMed
- Management of cancer-associated thrombosis in clinical practice was evaluated using the GARFIELD-VTE registry. The study emphasized the importance of real-world data on anticoagulant selection and patient outcomes.
86) Turpie AGG, Farjat AE, Haas S, Ageno W, Weitz JI, Goldhaber SZ, Goto S, Angchaisuksiri P, Kayani G, Lopes RD, Chiang CE, Gibbs H, Tse E, Verhamme P, Ten Cate H, Muntaner J, Schellong S, Bounameaux H, Prandoni P, Maheshwari U, Kakkar AK; GARFIELD-VTE investigators. 36-month clinical outcomes of patients with venous thromboembolism: GARFIELD-VTE. Thromb Res. 2023;222:31-9. 🔗 PubMed
- Thirty-six-month follow-up outcomes were reported for patients with venous thromboembolism. Mortality and recurrence rates should be considered when planning long-term treatment strategies.
87) Prandoni P, Haas S, Fluharty ME, Schellong S, Gibbs H, Tse E, Carrier M, Jacobson B, Ten Cate H, Panchenko E, Verhamme P, Pieper K, Kayani G, Kakkar LA; GARFIELD-VTE investigators. Incidence and predictors of post-thrombotic syndrome in patients with proximal DVT in a real-world setting: findings from the GARFIELD-VTE registry. J Thromb Thrombolysis. 2024;57(2):312-21. 🔗 PubMed
- Real-world data were used to analyze the incidence and risk factors of post-thrombotic syndrome in patients with proximal deep vein thrombosis. Early diagnosis and preventive strategies may reduce long-term complications.
